The Innovation: OLIGEN™ is a highly purified, patented phenolic extract derived from premium Extra Virgin Olive Oil. Standardized for exceptional yields of 55% Oleocanthal, 30% Oleacein, and 15% Hydroxytyrosol and Tyrosol derivatives, it represents a generational leap in botanical extraction.
The Anhydrous Advantage (Topical): Traditional water-based creams degrade active phenolics and require aggressive synthetic preservatives. Our 100% water-free (anhydrous) matrix ensures absolute stability of the OLIGEN™ complex. This eliminates the need for preservatives, ensuring zero stinging or burning upon application to vulnerable, ablated, or ulcerated skin.
Systemic Bioavailability (Internal): When utilized in our nutraceutical line, the OLIGEN™ complex delivers highly bioavailable antioxidants that actively contribute to the protection of cells from oxidative stress.
Clinical Evidence & Scientific Literature
THE EFFECTS OF OLEOCANTHAL HAVE BEEN PROVEN BY CLINICAL STUDIES
The foundational molecules utilized in GOLDMED formulations are the subject of extensive, peer-reviewed global research. The following published studies and clinical trials independently validate the profound physiological impacts of Oleocanthal and high-polyphenol Extra Virgin Olive Oil on human health.
(Note: The following literature is provided for professional, scientific, and educational review.)
Case Studies
Inflammation impact on modern human health
Further Studies on Oleocanthal
Katsa, M.E.; et al. Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic Patients: A Postprandial Study. Int. J. Mol. Sci. 2024, 25, 908.
Ignacio Ruiz-García et al. Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study. Clinical Nutrition, 42, 2023, 1389-1398.
Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer. Antioxidants (Basel). 2023 Dec 14; 12(12):2112.
Alaa H. Abuznait et al. Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies. ACS Chemical Neuroscience, 4.6 (2013), 973–82.
Oleocanthal Inhibits Catabolic and Inflammatory Mediators in LPS-Activated Human Primary Osteoarthritis (OA) Chondrocytes Through MAPKs/NF-κB Pathways. Cell Physiol Biochem. 2018; 49(6):2414-2426.
Agrawal, K et al. Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial. Journal of Functional Foods, 36, 84-93, 2017.
Xiuye Liu et al. Oleocanthal Protects against Neuronal Inflammation and Cardiopulmonary Bypass Surgery-Induced Brain Injury in Rats by Regulating the NLRP3 Pathway. Restorative Neurology and Neuroscience, 39.1 (2021), 39–44.
Segura Palacios JM et al. Topical treatment with oleocanthal extract in reducing inflammatory reactions after photodynamic therapy: a prospective quasi-experimental pilot study. Complement Ther Med. 2019; 42: 298-301.
Yazan S. Batarseh and Amal Kaddoumi. Oleocanthal-Rich Extra-Virgin Olive Oil Enhances Donepezil Effect by Reducing Amyloid-β Load and Related Toxicity in a Mouse Model of Alzheimer’s Disease. The Journal of Nutritional Biochemistry, 55 (2018), 113–23.
Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study. Medicina 2024, 60, 947.
Targeting PAR2-mediated inflammation in osteoarthritis: a comprehensive in vitro evaluation of oleocanthal's potential as a functional food intervention for chondrocyte protection and anti-inflammatory effects. BMC Musculoskelet Disord. 2024 Oct 1; 25(1):769.
Montoya T, Sanchez-Hidalgo, M et al. Dietary Oleocanthal Supplementation Prevents Inflammation and Oxidative Stress in Collagen-Induced Arthritis in Mice. Antioxidants, 10.5 (2021), 650.
Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheum. 2010 Jun; 62(6):1675-82.
Further Studies on High-Polyphenol Extra Virgin Olive Oil
Cardiovascular Health
Protection of LDL from oxidation by olive oil polyphenols is associated with a down regulation of CD40-ligand expression and its downstream products in vivo in humans. Am J Clin Nutr. 2012 May; 95(5):1238-44.
The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006 Sep 5; 145(5):333-41.
Extra virgin olive oil high in polyphenols improves antioxidant status in adults: a double-blind, randomized, controlled cross-over study (OLIVAUS). European Journal of Nutrition 2022, 1073-1086.
Post-prandial effects of high-polyphenolic extra virgin olive oil on endothelial function in adults at risk for type 2 diabetes: A randomized controlled crossover trial. International Journal of Cardiology, 330, 171-176.
Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: A randomized, crossover, controlled trial. Eur J Clin Nutr. 2008 Apr; 62(4):570-4.
Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: A randomized, crossover, controlled, clinical trial. Atherosclerosis, 2005 Jul; 181(1):149-58.
Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens 2012 Dec; 25(12):1299-30.
The Effect of High Polyphenol Extra Virgin Olive Oil on Blood Pressure and Arterial Stiffness in Healthy Australian Adults: A Randomized, Controlled, Cross-Over Study. Nutrients 2020, 12, 2272.
Effect of polyphenol-rich extra-virgin olive oil on lipid profile and inflammatory biomarkers in patients undergoing coronary angiography: A randomized, controlled, clinical trial. International Journal of Food Sciences and Nutrition, 72(4), 548–558.
Anti-Inflammatory Action
Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Beauchamp, Gary K. et al. Nature (2005), 437(7055), 45-46.
Oxidative Stress
Effect of olive oil phenols on oxidative stress biomarkers: A systematic review and dose-response meta-analysis of randomized clinical trials. Food Sci Nutr. 2023 Mar 13; 11(5):2393-2402.
Metabolic Syndrome
Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study. Metabolites. 2020 Oct 2; 10(10):392.
Central Nervous System
Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial. Nutrients 2022, 14, 5102.